50/49
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The septimal sixth-tone or jubilisma, 50/49, is the only superparticular comma aside from 126/125 which has a numerator which is neither square nor triangular, meaning it is not the difference between septimal superparticular rations with numerators differing by either one or two; instead, 50/49 = (10/7)/(7/5). Tempering it out equates the two, leading to temperaments where the square root of two does service for both. Equal temperaments tempering out 50/49 include 12, 22, 26, 38, 48 and 54edo.